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Researchers are uncovering the inner workings of TnpB, an ultra-small protein that cuts DNA just like bulky CRISPR systems. By understanding its tight molecular layout, scientists hope to turn it into an easy-to-deliver genetic editor.
Scientists have frozen snapshots of an avian jumping gene joined to CRISPR-Cas9, showing how it begins writing RNA messages directly into DNA.
A loop of non-coding RNA directly docks onto DNA and hijacks a key enzyme brake, switching on hundreds of genes that fuel pancreatic cancer.
In the common field poppy, plant self-incompatibility is controlled by two separate, unrelated gene pairs that share no common ancestry instead of a single shared gene family.
A lab study shows a virus small RNA copies the shape of engineered CRISPR guides, blocking bacterial defences by stealing their keyhole.
Inserting large genetic sequences into human T cells is vital for cellular therapies, but researchers must constantly trade high insertion rates against cell survival and genetic stability.
Researchers imaged natural protein complexes straight out of unpurified tardigrade extract at near-atomic detail.
Researchers demonstrated that a precise muscle-boosting gene edit in cattle safely passes to offspring without foreign DNA or harmful health abnormalities.
Scientists used CRISPR gene editing to disable the onion enzyme that makes eyes sting, cutting its activity down to a fifth of normal levels. However, spending years growing the altered cells in dishes left the resulting bulbs frail and unable to reproduce.
Researchers combined CRISPR scissors with viral repair enzymes to cleanly alter Agrobacterium tumefaciens, a microbe central to plant biology. The method allows scientists to rewrite the bacterium's genetic code step by step without leaving behind messy marks.