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#1NeuroscienceFront Page25 November 2025

Tiny Cellular 'Packages' May Reveal the Secrets of Migraine Auras

Researchers have analysed the protein cargo of tiny particles called extracellular vesicles released by neurons during cortical spreading depolarization. The findings reveal that neurons undergo complex structural and metabolic adaptations during migraine events, potentially offering a new way to track the condition via biomarkers.

By Sever-Bahcekapili, Cakir-Aktas, Güler, Onat, Solgun, Şahin, Belder, Erdener, Salih, Dalkara

#2NeuroscienceFront Page11 November 2025

Sparse Neurons Are Master Conductors of Brain's Blood Flow and Neural Rhythms

Researchers discovered that a sparse population of type-I nNOS neurons is essential for regulating the coordination of the brain's neural activity and blood flow. Their targeted removal led to significant disruptions in both neural signals and vascular responses, highlighting their indispensable role. This finding suggests that dysfunction or loss of these neurons may play a part in conditions like neurodegenerative diseases and sleep disorders.

By Turner, Brockway, Hossain, Griffith, Greenawalt, Zhang, Gheres, Crowley, Drew

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