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#1751Genetics & Molecular BiologyFront Page21 November 2025

DNA’s Stress-Reliever Can Mark the Spot for Cancer Mutations

Scientists have identified Topoisomerase IIb (TOP2B) as a crucial enzyme that, while resolving DNA tangles, marks specific regions prone to cancer-causing mutations. By analysing thousands of cancer genomes, the study reveals that TOP2B binding sites often coincide with genetic damage in critical driver genes.

By Uusküla-Reimand, Lee, Oh, Klein, Adler, Akhtar Alvi, Langille, Pasini, Cheng, Serafimova, Abd-Rabbo, Hou, Tsai, Bhat, Schramek, Wilson, Reimand

#1752Genetics & Molecular BiologyFront Page23 December 2025

Nanoimprinted Chips Optimise CRISPR/Cas9 Delivery for Potent T-Cell Therapy

Researchers have developed a Nanoimprinted Photothermal Chip (NPC) that uses near-infrared light to deliver gene-editing complexes with high precision. This method successfully disrupted the PD-1 gene in T cells, significantly boosting their antitumor activity while maintaining high cell viability.

By Chen, Zhu, Fan, Zhou, Li, Ge, Ning

#1753Chemistry & Material ScienceFront Page10 February 2026

Breathing Room: How Covalent Organic Frameworks Could Rescue Metal-Gas Batteries

Metal-gas batteries promise high energy density but suffer from sluggish reactions and internal degradation. A new review suggests that the precise, porous architecture of COFs offers a structural solution to these persistent bottlenecks.

By Wang, Yan, Peng, Shakir, Ma, Xu

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