Global Intelligence Database
By analysing human prefrontal cortex samples, researchers discovered that aging specifically targets excitatory neurons by restricting access to the EGR1 gene. This molecular 'locking' of the genome may stifle synaptic plasticity, offering a precise mechanism for cognitive decline.
By Guan, Wang, Zhou, Li, Zhao, Tian, Huang, Huang
A cross-sectional study reveals that patients with ACL reconstruction exhibit significantly smaller gray matter volume in pain-processing brain regions compared to healthy controls. These structural differences correlate with lower confidence in returning to physical activity.
By Zhang, Xue, Yang, Wang, Lu, Wang, Hua
A recent laboratory study demonstrates that clinically relevant doses of methylphenidate alter synaptic structural proteins differently in male and female brains. The findings expose significant flaws in older pharmacological models that failed to separate subjects by biological sex.
By Soares-Couto, Sá, Costa, Dias-Carvalho, Ferreira, Carvalho, Meisel, Capela
A specific neuromodulation protocol, cPAS25, successfully accelerates motor skill acquisition in healthy adults. While it modulates neural connectivity, the physiological effects interact complexly with active motor practice, suggesting a ceiling for induced plasticity.
By Sottana, Spampinato, Zeroual, Loi, Spinelli, Ginatempo, Deriu