Archived Intelligence
Modern biology generates more predictions than scientists can verify, while AI tools often lack reliability due to hallucinations. HypoChainer bridges this gap by combining human expertise, Large Language Models, and structured Knowledge Graphs to rigorously filter and refine scientific hypotheses.
While CRISPR-Cas9 is celebrated for precise genetic cuts, new research reveals it disrupts the epigenetic layer governing gene expression. These molecular 'scars' persist even when the DNA sequence is repaired perfectly, posing overlooked risks for gene therapies.
A five-year study reveals that nitrogen pollution impacts dry and wet grasslands in strikingly different ways. While biodiversity suffers in both, water availability determines whether the ecosystem grows more lush or simply changes its botanical makeup.
Researchers have devised a ruthless screening method using diphtheria toxin to identify superior versions of the Cas9 gene-editing enzyme. By selecting for variants that successfully perform precise Homology-Directed Repair (HDR) to survive the toxin, the study isolates tools capable of safer, more accurate gene therapy.
Researchers have developed an aluminium-nitrate battery that generates electricity while simultaneously synthesising ammonia from nitrate-rich wastewater. This dual-purpose system outperforms traditional methods by achieving exceptionally high production rates and offering a sustainable alternative to the energy-intensive Haber-Bosch process.
Researchers have successfully realised a fully functional dual-type quantum network node, integrating communication and memory qubits within a single ion species. By implementing a novel entangling gate that operates without cross-talk, the team has unlocked practical applications such as quantum-state teleportation.
Researchers have overcome a major hurdle in all-solid-state lithium metal batteries by addressing the chaotic flow of ions through sulfide electrolytes. By engineering a gradient of particle sizes, they achieved a stable 1,000-hour cycle with over 80% capacity retention.
Researchers have engineered a new iron-based material that switches its magnetic state in three distinct stages as temperatures shift. This rare multi-step behaviour, driven by a complex architectural framework, offers promising new avenues for high-density molecular data storage and sensing.
Researchers have unveiled a robust iridium(III)-catalysed method to transform flat pyridine rings into structurally complex piperidines. This selective process preserves delicate chemical groups often destroyed by traditional reduction, paving the way for novel pharmaceutical architectures.
A massive review of scientific literature reveals a historic fixation on pollution in the southern North Sea, leaving northern regions and climate impacts dangerously under-analysed. Experts warn that sustainable management is impossible without understanding how multiple human pressures interact simultaneously.
Researchers have discovered a counter-intuitive method to enhance optical devices by introducing structural disorder. This creates 'quasi-bound flat bands' that maintain high-quality light confinement across a wide range of angles, solving the fragility issues of previous photonic technologies.
New research reveals that the relationship between pupil dilation and brain arousal is far from simple. By stimulating the locus coeruleus in mice, scientists demonstrated that artificial arousal generates a distinct cortical signature compared to spontaneous alertness, mediated by specific adrenergic receptors.
A new algorithmic framework is bringing unprecedented clarity to underwater exploration. By fusing advanced edge detection with reinforcement learning, the system identifies submerged objects with over 92% accuracy, outperforming existing models.
High-energy x-ray diffraction is revolutionising our understanding of molten salts, crucial components in nuclear reactors and energy storage. By combining advanced photonics with machine learning, researchers are finally mapping the chaotic atomic structures of these superheated fluids.
Scientists have devised a high-yield method to pattern single photon emitters in hexagonal boron nitride with unprecedented precision. By combining focused ion beam milling with chemical vapour deposition, the research offers a scalable blueprint for the next generation of quantum technologies.
Researchers have successfully synthesised chains of organic radicals on a gold surface to model complex quantum magnetism. By balancing the magnetic interactions between the molecules and the metal substrate, the system achieves a 'quantum critical point', offering a new playground for simulating exotic heavy fermion physics.
Scientists have pinpointed distinct cellular changes in the brain tissue surrounding tumours that precipitate seizures. By identifying specific electrical anomalies known as paroxysmal depolarising shifts, clinicians may soon predict seizure risk with unprecedented accuracy.
A protein named RIN1 controls the molecular composition of spinal synapses, normally aiding development. However, nerve injury causes RIN1 levels to surge in adults, altering receptor structures and potentially rendering specific painkillers ineffective.
New research reveals that deleting the DAP12 gene in female mice prevents neurodegeneration, even as Alzheimer’s-related proteins accumulate. By blocking a specific signalling pathway, the brain preserves its protective myelin sheaths despite the pathology.
Researchers have sequenced the genome of the bagworm Eumeta crameri, uncovering the genetic blueprint behind its unique protective case. The study highlights adaptations in silk production and a specialised gut microbiome that aids survival.
A novel computational framework now maps the intricate dance between neurons, astrocytes, and blood vessels within the dorsal vagal complex. By integrating multiscale dynamics, this model illuminates how the brainstem regulates its own fuel supply, offering fresh insights into autonomic disorders.
A pioneering study maps the vertical distribution of single-celled organisms in the Bay of Bengal and Eastern Indian Ocean. Results show a dramatic shift from solar-powered surface communities to deep-sea ecosystems dominated by parasites and bacteria-eaters.
Captive-born male Senegalese sole are notoriously shy breeders, posing a major hurdle for European aquaculture. By mapping the full genetic 'recipe book' of the fish's nose, researchers hope to restore the chemical communication required for romance on the farm.
Researchers have identified a protein, OsPIL11, which acts as a natural limit on rice yield. Disabling this genetic regulator results in significantly heavier and more numerous grains, offering a clear target for breeding high-yield crop varieties.