Results for "Genetics & Molecular Biology"

ibRV Reveals Unprecedented Detail in Brain Circuit Development

Researchers developed a novel tool, the inducible barcoded rabies virus (ibRV), that enables temporal-controlled labeling of synaptic circuits with high-throughput single-cell genomics readout. This advanced method overcomes limitations of existing techniques, allowing for the dissection of neuronal circuit changes over time at single-cell and spatial resolution. It offers a deeper understanding of how circuits form and dysfunction, which is crucial for neurodevelopmental disorder research.

By Zhang, D'Arcy, He, Arroyo, Deasy, Matthews, Yan, Rastogi, Mancia Leon, Kaur, Southwell, Huang, Silver, Velmeshev