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#421Genetics & Molecular BiologyFront Page25 March 2026

Reversing CD8 T Cell Exhaustion: How a Lipid Metabolite Could Redefine Cancer Therapy

Researchers have identified that a lipid molecule called phosphatidylserine acts as an external brake on the immune system during chronic infections. Blocking this lipid with targeted antibodies in lab models revitalised failing immune cells, suggesting a novel pathway for future cancer and virology research.

By Medina, Sobierajska, Gong, McManus, Thapa, Lee, Im, Toombs, Mitchell, Wang, Carlisle, Freeman, Master, Ramalingam, Kissick, Li, Brekken, Ahmed

#422Genetics & Molecular BiologyFront Page25 March 2026

The Ice Age Exchange That Redefined Dog Domestication

Ancient DNA reveals that ice-age hunter-gatherers traded a single, homogeneous breed of dog across vast distances. Later migrations introduced new eastern canine genetics, fundamentally shaping the dogs we know today.

By Marsh, Scarsbrook, Yüncü, Hodgson, Lin, De Iorio, Thalmann, Thomas, Goor, Bergström, Noseda, Amiri, Biglari, Borić, Bougiouri, Carmagnini, Giannì, Higham, Lebrasseur, Linderholm, Mannino, Middleton, Mustafaoğlu, Perri, Peters, Richards, Sarıtaş, Skoglund, Stevens, Stringer, Tabbada, Talbot, Van der Sluis, Bello, Dimitrijevic, Martin, Mashkour, Parfitt, Vukovic, Brace, Craig, Baird, Charlton, Larson, Barnes, Frantz

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