
#2041NeuroscienceFront Page26 February 2026
Mapping Methylphenidate Brain Effects: How ADHD Drugs Alter Male and Female Synapses Differently
A recent laboratory study demonstrates that clinically relevant doses of methylphenidate alter synaptic structural proteins differently in male and female brains. The findings expose significant flaws in older pharmacological models that failed to separate subjects by biological sex.
By Soares-Couto, Sá, Costa, Dias-Carvalho, Ferreira, Carvalho, Meisel, Capela