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#1561Genetics & Molecular BiologyFront Page1 December 2025

Bespoke Tailoring: The Genetic Secrets of the Bagworm

Researchers have sequenced the genome of the bagworm Eumeta crameri, uncovering the genetic blueprint behind its unique protective case. The study highlights adaptations in silk production and a specialised gut microbiome that aids survival.

By Chakraborty, Mahajan, Prasoodanan P.K., Khamkar, Sharma

#1562Computer Science & AIFront Page13 November 2025

RNA Beacon Supercharges CRISPR for Cleaner Plant Gene Editing

Scientists have developed a powerful new tool to streamline plant gene editing. By replacing traditional fluorescent markers with a specialised RNA beacon, their system makes it dramatically faster and more efficient to find successfully edited plants that are free of the editing machinery, a crucial step for future agricultural applications.

By Liu, Bai, Zhan, Yao, Zhang, Yi, Dong, Li, Shen, Chen, Zhao

#1563Genetics & Molecular BiologyFront Page18 November 2025

Optimising CRISPR: A Robust New Framework for Stem Cell Editing

Researchers have engineered a highly efficient, inducible CRISPR/Cas9 system for human pluripotent stem cells, achieving single-gene knockout rates of up to 93 per cent. By systematically refining editing parameters and benchmarking prediction tools, the study identifies the Benchling algorithm as the superior method for selecting effective guide RNAs.

By Ni, Gong, Ran, Bai, Huang, Zheng, Zhou, Lan, Gu, Liu

#1564Genetics & Molecular BiologyFront Page22 December 2025

Scrutinising the Efficacy of Enterococcus faecalis CRISPR Typing in Malaysian Isolates

Researchers evaluated a novel primer set for identifying Enterococcus faecalis strains in Malaysia, finding CRISPR1-cas9 loci in half of the 26 samples. The data indicates that combining CRISPR1 and CRISPR2 analysis yields discriminatory power comparable to Multilocus Sequence Typing (MLST) at a reduced cost.

By Beh, Muzahid, Mar, Goh, Huët, Lim, Rahman

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