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#1101Genetics & Molecular BiologyFront Page25 November 2025

Unlocking the Molecular Secrets of Microscopic Synapses

Scientists have developed a new technique to characterise the proteins within specific, microscopic brain regions in the mouse hippocampus. This study reveals unexpected diversity in synaptic proteins and highlights how individual neurons regulate glutamate receptors to fine-tune communication.

By Reig-Viader, del Castillo-Berges, Burgas-Pau, Arco-Alonso, Zerpa-Rios, Ramos-Vicente, Picañol, Castellanos, Soto, Roher, Sindreu, Bayés

#1102Physics & AstronomyFront Page10 November 2025

3D Imaging Unveils Sub-Wavelength Light Confinement in Dielectric Nanocavities

Researchers have successfully used a novel 3D imaging technique to visualize how dielectric photonic nanocavities confine light within sub-wavelength volumes, a feat previously associated primarily with plasmonic structures. This breakthrough demonstrates the potential for strong light-matter interactions without the energy losses typical of metals, opening new avenues for advanced photonic and quantum technologies.

By Seifner, Darket, Babar, Vosoughi Lahijani, Christiansen, Sigmund, Semenova, Stobbe, Kristensen, Kadkhodazadeh

#1103Computer Science & AIFront Page10 November 2025

MetaboliteChat: Unifying Metabolite Analysis with Multimodal AI

Researchers introduce MetaboliteChat, a novel multimodal large language model that addresses the limitations of existing, narrow approaches for metabolite analysis. It integrates molecular-graph and image reasoning with natural language understanding to provide comprehensive, interactive insights into metabolite mechanisms and properties. This innovation is poised to advance metabolomics and systems biology by facilitating discovery across diverse biological systems.

By Guo, Duan, Liang, Patil, Xie

#1104Physics & AstronomyFront Page11 November 2025

Neutron Scattering Uncovers Hybrid Excitations from Magnetoelastic Coupling

In strongly correlated electron systems, magnetoelastic coupling, which links spins to lattice strains, fundamentally modifies low-lying elementary excitation spectra. This interaction means magnetic and lattice dynamics are no longer independent, leading to complex hybrid excitations. Inelastic neutron scattering spectroscopy is an indispensable tool for probing these intricate coupled phenomena.

By Ma, Lv, Li, Liu

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