Archived Intelligence
A retrospective study reveals a hierarchy in diabetes treatments regarding brain health. While GLP-1 receptor agonists appear superior to DPP4 inhibitors for reducing dementia risk, they surprisingly lag behind SGLT2 inhibitors.
Researchers have utilised the chemistry behind the Maillard reaction—responsible for browning food—to create a robust, recyclable polymer using maltose. This water-soluble material offers high tensile strength and self-repair capabilities without toxic catalysts.
A comprehensive review of the last decade reveals that green innovations are technically ready for mass deployment. However, the study indicates that outdated financial and political frameworks are currently stalling widespread adoption.
Scientists are reviewing the use of machine learning to accelerate the design of shape memory polymers, moving away from slow empirical methods. While algorithms show promise in predicting material behaviour, the field faces significant hurdles in modelling complex thermal and temporal effects.
Researchers exposed pregnant mice to valproic acid to study its impact on offspring behaviour and brain chemistry. The study revealed that exposed mice developed anxiety and social issues, coinciding with a surprising spike in the protein Klotho within the frontal cortex.
By treating fishing fleets as biological sensors rather than just industry, researchers discovered that vessel movements accurately predict ecological shifts caused by warming waters. This data offered warnings of fishery collapses a full year ahead of official government declarations.
New research in mice indicates that cerebellar climbing fibres can inhibit the strengthening of neural connections in the somatosensory cortex. This interaction appears to be mediated by a specific pathway involving the zona incerta.
A systematic review of 18 studies identifies a specific cluster of brain activity in the left parietal lobe associated with ASMR. While findings suggest potential for emotional regulation, the data highlights the need for standardised testing methods.
Researchers have engineered a sequential electrochemical process that replaces the inefficient oxygen evolution reaction with methanol oxidation. By utilising a nickel-based catalyst cycle, the system produces hydrogen and high-value formic acid with 95% Faraday efficiency.
A systematic review analysed recent trials for EGPA therapies, finding that rituximab offered no clear advantage over standard care. Meanwhile, benralizumab showed efficacy comparable to mepolizumab.
A comprehensive review examines how merging three distinct catalytic cycles may overcome traditional synthetic limitations. The authors argue this approach enhances selectivity and enables complex reactions under milder conditions.
Researchers evaluated a novel primer set for identifying Enterococcus faecalis strains in Malaysia, finding CRISPR1-cas9 loci in half of the 26 samples. The data indicates that combining CRISPR1 and CRISPR2 analysis yields discriminatory power comparable to Multilocus Sequence Typing (MLST) at a reduced cost.