Archived Intelligence
Researchers demonstrated that a single dose of an adenine base editor, delivered via AAV9, successfully corrected the pathogenic mutation in a mouse model of ADPKD. The study highlights that both broad and kidney-specific gene editing can delay cyst growth and improve survival rates.
Previous models assumed chlorophyll f was merely a passive antenna for light collection. New structural data proves it actively drives electron transfer, allowing organisms to power themselves with low-energy, far-red light.
New structural analysis challenges the consensus that Chlorophyll f is photochemically inert. By mapping the A-1B site in cyanobacteria, researchers propose a direct role for the pigment in low-energy photosynthesis.
Researchers have identified N4BP2 as a cytoplasmic enzyme that enters ruptured micronuclei to fragment DNA. This process drives chromothripsis and the formation of extrachromosomal DNA, fueling rapid tumour evolution and growth.
Researchers have mapped the atomic structure of cerebellar AMPA receptors, revealing distinct compositions for neurons and glia. The findings explain how specific protein arrangements dictate calcium permeability and synaptic delivery.
Researchers have defined the structural composition of cerebellar AMPA receptors, distinguishing between neuronal and glial subtypes. The study reveals how specific subunit combinations and domain shapes dictate calcium permeability and synaptic trafficking speed.
Researchers have identified how two distinct inputs from the lateral entorhinal cortex work in synergy to regulate memory circuits in mice. By balancing excitation and inhibition, these pathways stabilise spatial maps essential for long-term learning.
New research reveals that nerve insulation does more than simply accelerate signals; it preserves the rhythm of high-speed neural bursts. Without this protective layer, the precise timing required for sensory processing falls apart.
Researchers have identified and resolved a microscopic insulating barrier within the hole transport layer of solar cells. By introducing Triton X-100, the team achieved a record 25.4% efficiency, paving the way for high-performance wearable and aerospace photovoltaics.
Researchers have pinpointed Hepatic Leukaemia Factor (HLF) as a master regulator that instructs immune cells to remain in tissues and drive inflammation. In animal models, removing the gene responsible for HLF successfully prevented chronic airway inflammation.
High-resolution satellites identified over 3,000 energy sites responsible for massive methane output in 2023. Coal facilities emitted significantly more frequently than oil and gas infrastructure, active nearly half the time they were observed.
Researchers have identified N4BP2 as the specific cytoplasmic nuclease that fragments DNA within ruptured micronuclei. This damage drives massive genomic rearrangement, tumour evolution, and drug resistance.
Researchers have successfully engineered a circuit where single photons interact via a quantum dot, overcoming a fundamental limitation of light-based computing. This programmable system allows for complex nonlinear operations necessary for simulating molecular dynamics.
Researchers report that thermal infrared radiation serves as a specific pollination signal for beetles, facilitated by mitochondrial heating and specialised antennal sensors. The data suggests this sensory modality may be an ancient precursor to visual cues.
Researchers successfully used an adenine base editor delivered via AAV9 to correct genetic mutations in mouse models of ADPKD. The study demonstrates that both whole-body and kidney-specific approaches can delay cyst growth and improve survival rates in specific strains.
Researchers investigated how neural insulation affects communication between brain regions in mice. They discovered that myelin does more than simply accelerate signals; it preserves the integrity of high-speed data bursts to ensure precise timing.
An analysis of 45 North American jay genomes reveals a 100-megabase reduction in genome size driven by satellite shifts. The study confirms that population size dictates whether complex genomic mutations are purged or preserved.
Researchers have identified Hepatic Leukaemia Factor (HLF) as the master transcription factor that instructs T cells to settle in tissues and promote inflammation. Blocking this factor in mice significantly reduced airway inflammation.
Researchers have identified a dual-signal mechanism in mice where long-range inputs balance excitation and inhibition to stabilise spatial memories. This push-pull dynamic ensures that neuronal maps remain consistent over time.
Researchers have identified a microscopic phase separation in common conductive films that creates an insulating barrier in solar devices. By introducing a surfactant to homogenise the layer, they achieved a record 25.4% efficiency for flexible tandem cells.