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#981Genetics & Molecular BiologyFront Page17 November 2025

Tuning CRISPR for the Brain's Nondividing Cells

New research reveals that nondividing cells, such as neurons, repair DNA damage far differently than their dividing counterparts. By understanding these unique mechanisms, scientists can now control gene editing outcomes with greater precision in critical human tissues.

By Ramadoss, Namaganda, Kumar, Hamilton, Sharma, Chow, Workley, Macklin, Sun, Ha, Liu, Fellmann, Watry, Dierks, Bose, Jin, Perez, Sandoval Espinoza, Matia, Lu, Judge, Shy, Nussenzweig, Adamson, Murthy, Doudna, Kampmann, Conklin

#982Medicine & HealthFront Page5 January 2026

The Unseen Barrier: Rewriting the Rules of Nanoparticle Drug Delivery

The body's blood vessels act as a strict border control, often blocking medicines from reaching their targets. A new review details how engineering nanoparticles to mechanically reprogramme these linings could turn a lucky leak into a predictable path for treatment.

By Ma, Yang, Deng, Zhao, Tian, Zhang, Yu, Yan, Yue

#983Genetics & Molecular BiologyFront Page15 December 2025

Cellular Senescence: Disrupting Metabolic Loops to Reverse Ageing Signs

Researchers have identified a metabolic interaction involving PGAM1 and Chk1 that allows senescent cells to evade apoptosis. Blocking this pathway in mice successfully eliminated these cells and reduced lung fibrosis.

By Mikawa, Kameda, Ikari, Shibata, Liu, Miyagawa, Ono, Ito, Yoshizawa, Sugimoto, Shibuya, Shimizu, Almunia, Ogiso, Revêchon, Palazzo, Bernard, Kanda, Soga, Takubo, Morioka, Sasaki, Sasaki, Itamoto, Fujii, Seno, Inagaki, Kondoh

#984NeuroscienceFront Page17 November 2025

Hundreds of Genes Linked to Anxious Feelings Uncovered in New Study

By combining genomic data with models of gene activity in the brain, researchers have identified hundreds of genes associated with feelings of worry and anxiety. This genetic blueprint not only provides new targets for research but also reveals a shared biological foundation with conditions like autism and schizophrenia.

By Sharma, Wheeler

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