Global Intelligence Database
Once dismissed as a temporary intermediate in DNA maintenance, 5-hydroxymethylcytosine (5hmC) is now recognised as a crucial regulator of gene expression. New research highlights its potential as a powerful biomarker for cancer detection and a key factor in determining how tumours respond to chemotherapy.
By Kharat, Sharan
A massive analysis of over 4,000 patients reveals that detailed smoking history dictates the efficacy of immune checkpoint inhibitors. While smokers exhibit a pro-inflammatory environment suited for monotherapy, non-smokers appear to require chemotherapy combinations to unlock similar survival benefits.
By Wang, Ricciuti, Elkrief, Alessi, Di Federico, Pecci, Nishino, Gulhan, Ananda, Rodig, Sholl, Johnson, Lin, Schoenfeld, Awad, Christiani
It seems logical that a drought, which weakens prey, would be a boon for large predators. Yet, a new study reveals a more complex reality, finding that subordinate leopards suffered a dramatic decline in cub survival despite easier hunting, showcasing how a carnivore's rank dictates its fate in a changing climate.
By Balme, Woodgate, Hunter, Balme