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#811Medicine & HealthFront Page13 November 2025

Breaking the Ceiling: A New Strategy for IBD Treatment

Scientists are tackling a major challenge in treating inflammatory bowel disease (IBD): powerful biologic therapies often lose effectiveness over time. A new commentary argues for a smarter approach, using treatments earlier and in a carefully planned sequence to overcome this resistance and improve long-term outcomes.

By Valdiserra, Fantini, Favale, Antonioli

#812Analysis

#813Genetics & Molecular BiologyFront Page11 November 2025

AstraBIND: Rapid AI Predicts Ligand Binding Sites for Accelerated Drug Discovery

AstraBIND is a lightweight graph neural network designed to rapidly identify ligand binding sites and ligand types in proteins. By integrating sequence, structure, and homology data, it overcomes previous trade-offs between accuracy and computational cost, making it a powerful tool for drug discovery and protein design.

By Goteti, Bozkurt, Vasilyeva

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