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Results for "Genetics & Molecular Biology"

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#791Genetics & Molecular BiologyFront Page25 November 2025

Existing Drug Repurposed for Rare Autism via Genetic Fingerprinting

Researchers utilised a high-throughput platform to analyse the genetic 'fingerprint' of a rare form of autism called 19q12 ASD. By screening existing drugs, they discovered that entrectinib could reverse the disease's genetic signature, leading to successful off-label treatment in a patient.

By Guin, Haditsch, Bellucci, Topka, Dyer, Del Toro, Blanco, Downs, Perfito, Mahadevan, Moxham

#792Computer Science & AIFront Page20 November 2025

AI Model Uncovers Hidden Risks in Drug Combinations

A new computational framework called IMF-DDI is transforming how scientists predict dangerous drug-drug interactions. By fusing data from multiple external sources rather than relying solely on direct drug connections, the model achieves state-of-the-art accuracy in forecasting clinical safety risks.

By Li, Zhang, Liu, Lu, Ma, Li, Kitsuregawa, Gu

#793Genetics & Molecular BiologyFront Page12 November 2025

Rewiring the Genome: Engineering 3D Architecture to Understand Cell Function

Scientists are tackling a fundamental challenge in understanding the causal link between the 3D organization of our genome and how cells function. New genome engineering techniques allow for targeted manipulation of DNA loops, offering a way to move beyond correlative observations and directly investigate how genome structure dictates gene expression, ultimately advancing synthetic biology.

By Petersen, Westermann, Smialkovska, Mathony, Feldmann, Niopek

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