Results for "Genetics & Molecular Biology"

HLF Identified as the Genetic Architect of CD4+ Tissue-Resident Memory T Cells

Researchers have pinpointed Hepatic Leukaemia Factor (HLF) as a master regulator that instructs immune cells to remain in tissues and drive inflammation. In animal models, removing the gene responsible for HLF successfully prevented chronic airway inflammation.

By Kiuchi, Nemoto, Yagyu, Aoki, Iwamura, Sugimoto, Masuo, Morita, Ma, Okuno, Hishiya, Tsuji, Sasaki, Kokubo, Ohishi, Shinmi, Sonobe, Iinuma, Yonekura, Yokomizo, Komatsu, Onodera, Okumura, Ito, Hatano, Tsuruyama, Kurashima, Mato, Suzuki, Kimura, Motohashi, Kawakami, Ueno, Tumes, Hanazawa, Nakayama, Hirahara