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#711Medicine & HealthFront Page14 November 2025

AI Assistant Decodes Disease Networks to Find New Drug Targets

Scientists have launched a powerful new bioinformatics tool that combines vast biological datasets with an AI language model to accelerate drug discovery. The Target and Biomarker Exploration Portal (TBEP) uses machine learning to analyse complex networks of genetic and protein data, helping researchers to identify novel drug targets that traditional methods often miss.

By Dewangan, Ray, Ren, Srivastava, Jiang, Ojha, Xu, Srivastava

#712Genetics & Molecular BiologyFront Page15 November 2025

How Molecular Engines Fuel Pancreatic Cancer's Identity

Pancreatic cancer cells utilise a protein called KLF5 to switch between different identities, a trait that aids their survival. New research reveals that KLF5 relies on two energy-burning enzymes, RUVBL1 and RUVBL2, to function, offering a promising new target for drug development.

By Cunniff, Sivetz, Skopelitis, Klingbeil, Toobian, Maia-Silva, Egeblad, Vakoc

#713Genetics & Molecular BiologyFront Page14 January 2026

The Stubborn Bean: New frontiers in CRISPR/Cas9 genome editing in legumes

Legume crops are vital for sustainable agriculture but have historically resisted genetic modification due to biological recalcitrance. A new review details how advanced editing tools and AI are finally bridging the gap between genomic knowledge and field application.

By Kumar, Yadav, Mahakalkar, Mandlik, Vats, Thakral, Kumar, Nishad, Nichal, Deshmukh, Sharma, Sonah

#714Medicine & HealthFront Page13 November 2025

Single Gene Flaw Reveals How Iron Mishandling Sparks Neurodegeneration

By introducing a single genetic mutation into mice, scientists have pinpointed how a faulty iron-regulating protein triggers a rare neurodegenerative disease. This new animal model demonstrates that disrupting the cell’s delicate iron balance leads directly to memory loss, motor deficits, and inflammation in the brain, offering a crucial window into iron-driven neurological disorders.

By Guo, Lv, Huang, Shao, Zhang, Hao, Hao, Cheng, Liao

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