Global Intelligence Database
Researchers propose a 'scarless' circular mRNA platform designed to improve the stability of CAR-T therapies. Pre-clinical data indicates superior durability and antitumour activity compared to standard linear mRNA, though human efficacy remains unproven.
By Hu, Zhao, Zhou, Tian, Wang, Hua, Zhang
Researchers have mapped how specific genetic errors disrupt cellular function and cause severe epilepsy. By testing an existing drug in the lab, they found a way to bypass the mutation and restore normal protein production.
By Di Nardo M, Sardina F, Pallotta MM, Marcos-Alcalde I, Gómez-Puertas P, Rinaldo C, Krantz ID, Musio A.
Researchers combined blood sample data from healthy adults and bariatric surgery patients to create a dataset capable of exploring the chemical changes associated with weight and intentional weight loss. By measuring thousands of microscopic molecules, scientists have built a foundation to investigate the hidden biological shifts that occur when the body sheds significant mass.
By Smith, Goudswaard, Hughes, Blazeby, Rogers, Mazza, Gidman, FitzGibbon, Groom, Ring, Northstone, Matthews, White, Fabian, Timpson, Corbin