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Results for "Genetics & Molecular Biology"

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FOUND 486 MATCHESTIME: 617ms

#471Genetics & Molecular BiologyFront Page22 December 2025

Scrutinising the GPCR Activation Mechanism: Ligand Efficacy and Kinetic Traps

Researchers employed time-resolved cryo-EM to visualize intermediate states of the μ-opioid receptor under non-equilibrium conditions. The findings propose that ligand efficacy correlates with specific structural dynamics, suggesting partial agonists may induce a stalled state during activation.

By Robertson, Modak, Papasergi-Scott, Hu, Peroto, Varga, Majumdar, Kalathur, Blanchard, Skiniotis

#472Chemistry & Material ScienceFront Page9 January 2026

From Propane to Artemisinin: A Smarter Route to Oxime Synthesis

Researchers have developed a method to convert abundant hydrocarbons directly into oximes using a manganese catalyst. This approach targets stable methylene C-H bonds, bypassing the need for expensive, pre-functionalised starting materials.

By Song, Li, Xie, Zhang, Weilian, Wang, Steiner, Sun, Wang, Xiao, Li

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