
#451Genetics & Molecular BiologyFront Page5 February 2026
The Silent Wire: Rethinking Enhancer-Promoter Communication in the Nucleus
A new study challenges the assumption that cohesin loops are always necessary for genes to talk to their distant regulators. By engineering stem cells to break these loops, researchers found that many genes maintain their expression through alternative, robust mechanisms.
By Hansen, Adachi, Braccioli, Kadvani, Boileau, Martinovic, Pokorny, Shah, Anderson, Zhang, Carel, Bonitto, Blelloch, Fudenberg, de Wit, Nora