Global Intelligence Database
Bacteria use temporary chemical tags to hide from antibiotics without changing their core DNA. A new review explores how tracking these epigenetic disguises could help us defeat drug-resistant superbugs.
By Daaboul, El Hayek, Sarraf, Yazbek, Yazbek, Khoury, Tokajian
Scientists have struggled to directly drug a major cancer-driving protein. A new CRISPR screening method has successfully mapped the upstream genetic switches that control it in lab models, offering fresh targets for researching multiple myeloma over the next decade.
By Seibert, Kurrle, Kaleab, Wempe, von Metzler, Serve, Schnütgen
Researchers used a modified CRISPR technique to crank up the volume on thousands of genes, identifying which ones help immune cells survive inside hostile solid tumours.
By Wong, Souza‐Fonseca‐Guimaraes
Scientists have mapped the genetic instruction manual of a highly salt-resistant plant. By observing exactly which genes activate when the plant is exposed to salt, researchers hope to breed future crops that can thrive in degraded soils.
By Li, Zhou, Wu, Golenberg, Zhu, He, Fan