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Results for "Genetics & Molecular Biology"

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#261Genetics & Molecular BiologyFront Page12 January 2026

Beyond Immunotherapy: The Future of NF2-mutated Renal Cell Carcinoma

A new study reveals that NF2 inactivation in renal cell carcinoma drives an aggressive, immune-resistant phenotype. The findings suggest that standard immunotherapy may be ineffective for these patients, highlighting an urgent need for molecularly targeted alternatives.

By Yekedüz, Bian, Siegmund, Machaalani, El Masri, Saleh, Saad, Ascione, El Hajj Chehade, Steiner, Barrios, Berg, McGregor, Mantia, Ravi, Xu, Hirsch, Choueiri, Serzan

#262Computer Science & AIFront Page12 January 2026

AI in Drug Discovery: Engineering Superior Peptides for Endometrial Cancer

A multi-stage deep learning pipeline successfully generated and screened over 14,000 peptide structures, identifying candidates with binding affinities surpassing the clinical reference drug Capivasertib. Molecular dynamics simulations confirm these novel compounds maintain structural stability and favourable pharmacokinetic profiles.

By Fatima, Rehman, Wang, Ur Rehman, Aldaw, Warraich, Meng, Li, Liao

#263Chemistry & Material ScienceFront Page6 February 2026

Molecular Chaperones: Bringing Order to Wide-Bandgap Perovskite Solar Cells

Researchers have utilised a symmetric molecule, H3TATB, to resolve the chaotic halide segregation often seen in perovskite films. By slowing crystallisation and shepherding bromine ions, the additive boosts efficiency to over 19% while significantly improving stability.

By Wang, Zhang, Sun, Wang, Li, Cai, Duan, Ma, Pan, Hu

#264Genetics & Molecular BiologyFront Page10 November 2025

Novel Genetic Variants Identified for Knee Osteoarthritis in South Indian Population

A recent study employed whole-exome sequencing to identify seven rare, putatively pathogenic genetic variants contributing to knee osteoarthritis in South Indian patients. These variants, notably absent from existing clinical variant databases and genome-wide association datasets of European and East Asian ancestry, suggest population-specific contributions to disease susceptibility. The findings underscore the importance of extending genomic studies to underrepresented groups for a comprehensive understanding of population-specific genetic risk factors in osteoarthritis.

By Vijetha, Hari, Jeyaraman, Kanta, Annamalai, Palodhi, Zawar, Suravajhala

#265Genetics & Molecular BiologyFront Page10 November 2025

Deep Connections: Eastern Mediterranean Sponge Grounds as Refugia

New research reveals the genetic connectivity of the sponge Axinella polypoides between shallow and mesophotic zones in the Eastern Mediterranean. This connectivity supports the role of mesophotic sponge grounds as refugia for A. polypoides, and potentially for other species, including those threatened from shallower habitats. These findings emphasize the importance of protecting these habitats, especially given increased anthropogenic and climate-driven pressures.

By Morav, Taboada, Goren, Idan, Shefer, Tikochinski, Sancha, Pérez, Coma, Ilan

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