#2651NeuroscienceFront Page4 March 2026
The Double-Edged Sword of Brain Ageing: How the NLRP3 Inflammasome Drives Cognitive Decline
The NLRP3 inflammasome acts as a biological bouncer in the brain, protecting neural health in youth but driving inflammation and memory loss in middle age. This discovery suggests that future anti-ageing therapies must be carefully timed to avoid harming early-life brain plasticity.
By Komleva, Khilazheva, Mosiagina, Panina, Belozor, Shuvaev, Lukyanchuk, Blagova, Satish, Malinovskaya, Berdalina, Salmina, Illarioshkin