Global Intelligence Database
Researchers have discovered that mutations at the very same location on the p53 protein drive ovarian cancer resistance through entirely different mechanisms. One specific variant relies on unique partners, such as the protein CHD1, opening the door for highly specific precision therapies.
By Liu, Zheng, Ni, Mao, Xiao, Zhao, Tian, Wang, Xu, Hua
A new study reveals that NF2 inactivation in renal cell carcinoma drives an aggressive, immune-resistant phenotype. The findings suggest that standard immunotherapy may be ineffective for these patients, highlighting an urgent need for molecularly targeted alternatives.
By Yekedüz, Bian, Siegmund, Machaalani, El Masri, Saleh, Saad, Ascione, El Hajj Chehade, Steiner, Barrios, Berg, McGregor, Mantia, Ravi, Xu, Hirsch, Choueiri, Serzan
A multi-stage deep learning pipeline successfully generated and screened over 14,000 peptide structures, identifying candidates with binding affinities surpassing the clinical reference drug Capivasertib. Molecular dynamics simulations confirm these novel compounds maintain structural stability and favourable pharmacokinetic profiles.
By Fatima, Rehman, Wang, Ur Rehman, Aldaw, Warraich, Meng, Li, Liao
Researchers have utilised a symmetric molecule, H3TATB, to resolve the chaotic halide segregation often seen in perovskite films. By slowing crystallisation and shepherding bromine ions, the additive boosts efficiency to over 19% while significantly improving stability.
By Wang, Zhang, Sun, Wang, Li, Cai, Duan, Ma, Pan, Hu