
#231NeuroscienceFront Page21 November 2025
Blocking a Rogue Protein Could Reverse Cognitive Decline in Alzheimer's Models
Researchers have discovered that a protein called DAPK1 triggers the destruction of a protective enzyme, leading to toxic tau buildup in the brain. Blocking DAPK1 in mice restored this protective enzyme and significantly improved memory and cognitive function.
By Shui, Zheng, Wu, Zhang, Kim, Chen, Peng, Wang, Zheng, Zhang, Li, Wang, Zhou, Kim, Chen, Zhang, Lee