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#221NeuroscienceFront Page26 November 2025

Thyroid Imbalance During Pregnancy Sparks Brain Inflammation in Offspring

Researchers have discovered that low levels of thyroxine during pregnancy trigger an inflammatory response that disrupts foetal brain development in mice. This condition leads to structural deficits in the hippocampus, but restoring hormone levels can prevent the damage.

By González-Madrid, Rangel-Ramírez, Opazo, Espinoza, Elgueta, Cancino, Mery, Ardiles, Duarte, Soto, Carreño, Simon, Bueno, González, Kalergis, Riedel

#222Medicine & HealthFront Page14 November 2025

Beyond the Spark: Atrial Fibrillation Remodels the Heart's Engine

A new study in horses reveals that persistent atrial fibrillation, a common heart rhythm disorder, is not just an electrical problem. Researchers found the condition causes significant structural and metabolic remodelling in the heart's atrial chambers, with surprisingly few changes to the ion channels that govern electrical signals. This suggests that tackling these underlying physical changes, rather than solely the electrical disturbance, could be key to more effective treatments.

By Haugaard, Nissen, Schneider, Birk, Carstensen, Hopster‐Iversen, Altıntaş, Barrès, Kjøbsted, Wojtaszewski, Herum, Jespersen, Buhl

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