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#2091Medicine & HealthFront Page15 November 2025

The Brain's Double-Edged Guardian: Meet the REST Protein

A crucial protein known as REST masterfully directs gene activity, shaping the developing brain and protecting it during normal ageing. However, when this powerful regulator falters, it becomes implicated in serious neurodegenerative diseases, making it a major focus for new therapeutic strategies.

By Eva, Shenoy, Gupta, Palanivel, Salkar, Nasab, Chitranshi, Mirzaei, You, Graham, Basavarajappa, Gupta

#2092NeuroscienceFront Page26 November 2025

Thyroid Imbalance During Pregnancy Sparks Brain Inflammation in Offspring

Researchers have discovered that low levels of thyroxine during pregnancy trigger an inflammatory response that disrupts foetal brain development in mice. This condition leads to structural deficits in the hippocampus, but restoring hormone levels can prevent the damage.

By González-Madrid, Rangel-Ramírez, Opazo, Espinoza, Elgueta, Cancino, Mery, Ardiles, Duarte, Soto, Carreño, Simon, Bueno, González, Kalergis, Riedel

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