
#1881Genetics & Molecular BiologyFront Page25 March 2026
Reversing CD8 T Cell Exhaustion: How a Lipid Metabolite Could Redefine Cancer Therapy
Researchers have identified that a lipid molecule called phosphatidylserine acts as an external brake on the immune system during chronic infections. Blocking this lipid with targeted antibodies in lab models revitalised failing immune cells, suggesting a novel pathway for future cancer and virology research.
By Medina, Sobierajska, Gong, McManus, Thapa, Lee, Im, Toombs, Mitchell, Wang, Carlisle, Freeman, Master, Ramalingam, Kissick, Li, Brekken, Ahmed