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Results for "Genetics & Molecular Biology"

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#171Genetics & Molecular BiologyFront Page20 November 2025

Tailor-Made Genomes: Why Custom Maps Beat Generic References

Reliance on a single generic reference genome hinders the analysis of complex laboratory cell lines due to extensive genetic variation. A new study demonstrates that using an 'isogenomic' reference—one specifically matched to the experimental cell line—drastically improves the accuracy of sequencing, gene editing, and structural mapping.

By Corda, Volpe, Dallali, Di Tommaso, Colantoni, Guarracino, Chittoor, Capulli, Tassone, Giunta

#172Computer Science & AIFront Page15 November 2025

The Genetic Switch Fuelling a Rice Revolution

To create high-yielding hybrid rice, scientists employ a clever genetic tool called male sterility. By preventing plants from self-pollinating, breeders can precisely control crosses, leading to more productive and robust crops to help secure the global food supply.

By Behera, Samal, Mishra, Sahoo, Dash, Mishra

#173Genetics & Molecular BiologyFront Page17 November 2025

Decoding the Genetic Signals of Childhood Leukaemia

A comprehensive meta-analysis involving over 1,645 patients has clarified which genetic markers reliably predict survival in paediatric acute myeloid leukaemia (AML). While WT1 overexpression and KIT mutations were confirmed as warning signs for poorer outcomes, other common mutations showed surprisingly inconsistent effects.

By Huang, Ling, Zhang, Zhang

#174Medicine & HealthFront Page21 November 2025

Linking Blood, Brain, and Behaviour: A New Multi-Omics View of Schizophrenia

By combining blood gene analysis with brain imaging, researchers have identified specific genetic markers that correlate with the functional brain changes and symptoms of schizophrenia. The study highlights six key genes that may serve as a bridge between molecular biology and clinical reality.

By Zhao, Wang, Liu, Guo, Wang, Gao, Liu, Wu, Wu, Zhang, Yuan, Zhu, Ma, Cui, Zhang

#175Genetics & Molecular BiologyFront Page22 November 2025

Genetic Fingerprints Distinguish Aggressive Oral Lesions from Benign Patches

Researchers have identified distinct genetic and molecular differences between common oral leukoplakia and its more dangerous counterpart, proliferative verrucous leukoplakia. The discovery of specific variants in the Syndecan 3 gene offers a promising new biomarker for early diagnosis and prognostic prediction.

By Pérez-Sayáns, Silva, Fernández-Rozadilla, Carracedo, Carlés-González, Lorenzo-Pouso, Pérez-Jardón, Gándara-Vila, García-García, Suárez-Peñaranda, Blanco-Carrión, Chamorro-Petronacci

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