Global Intelligence Database
Researchers have identified that mitochondrial ribosomal protein S12 (MRPS12) is overactive in non-small cell lung cancer and linked to poor patient outcomes. Silencing this protein cripples the cancer cells' energy production and halts tumour growth in animal models.
By Chen, Jin, Wei, Wei, Ding
KG-SLomics is an advanced AI model that predicts synthetic lethality (SL) in cancer by integrating a vastly updated knowledge graph with multiomics data. This approach identifies critical gene pairs whose combined alteration leads to cancer cell death, offering a promising strategy to target otherwise 'undruggable' cancer mutations. By outperforming existing methods and suggesting novel therapeutic targets, KG-SLomics demonstrates significant clinical potential for personalized cancer therapies.
By Lee, Nam
Scientists used CRISPR-Cas9 to eliminate MADD, a protein crucial for the survival and spread of anaplastic thyroid cancer (ATC) cells. This deletion significantly impaired cancer cell function in lab dishes and dramatically suppressed tumor growth and metastasis in mice. The findings suggest MADD could be a promising new therapeutic target for this deadly and hard-to-treat cancer.
By Bakthavachalam, Sanborn, Mathayan, Salunkhe, Wood, Maienschein-Cline, Setty, Kabeer, Rehman, Prabhakar
Scientists have created the first predictive map of Antarctic seafloor biodiversity, highlighting unique hotspots concentrated in cold, food-rich environments. This groundbreaking work exposes the vulnerability of these ecosystems to ocean warming and reveals that only a small fraction of these critical areas are currently protected, underscoring an urgent need for expanded conservation efforts.
By Jansen, Boeira-Dias, Gros, Johnson, Hill
Researchers found that a specific protein sensor worsens brain injury when blood flow is restricted. By genetically removing or chemically blocking this receptor in mice, the study reduced neuronal death and preserved the blood-brain barrier.
By Castañeda-Arellano, García-Lara, Angeles-López, Pérez-Severiano, Elizondo-Azuela, Dueñas-Jimenez, González-Pozos, Aguilar-García, Segovia