#1751Genetics & Molecular BiologyFront Page4 December 2025
A Sticky Situation: How Cellular Adhesion Undermines Chemotherapy
New research identifies a rogue alliance between proteins CDC6 and Tmod3 as a primary driver of resistance to the common chemotherapy drug paclitaxel. By stabilising the cancer cell's internal skeleton and helping it anchor firmly, this interaction prevents the drug from taking effect, suggesting a novel target for combination therapies.
By Liu, Wang, Zhan, Sun, Sun, Fu, Lv, Li, Dong, Lou
