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#1601Medicine & HealthFront Page14 November 2025

Proposed Biomarker for Rare Cartilage Disease Fails Scientific Scrutiny

A long-proposed antibody test for relapsing polychondritis, a rare inflammatory disease, has been shown to be unreliable. A major new analysis, combining a prospective study with a systematic review, found the anti-collagen II antibodies are neither sensitive nor specific, making them unsuitable for diagnosing or monitoring the condition.

By Stonick, Ferrada, Fike, Quinn, Turturice, Stein, Grayson

#1602Medicine & HealthFront Page15 November 2025

A Quicker, Breath-Easy Path to Detailed Heart Scans

Researchers have developed a new cardiac MRI method that generates three crucial diagnostic maps of the heart simultaneously, all in under five minutes. Crucially, the technique works while the patient breathes freely, removing the need for uncomfortable breath-holds and simplifying the scanning process.

By Mai, Kara, Liu, Moura, Sadighi, Kanj, Wexler, Sosnovik, Hanna, Santangeli, Nakagawa, Wazni, Chen, Tang, Tandon, Kwon, Nguyen

#1603NeuroscienceFront Page14 November 2025

How You Breathe Redirects Your Brain’s Neural Traffic

New imaging research reveals that nasal and oral breathing engage distinct brain networks. While mouth breathing triggers survival-oriented regions, nasal respiration boosts connectivity in areas associated with higher-level cognition.

By Mohammadi, Hossein-Zadeh, Raoufy

#1604NeuroscienceFront Page26 November 2025

The Limbic Legacy: COVID-19’s Subtle Etchings on Brain Architecture

While COVID-19 survivors do not exhibit global brain shrinkage, a new multimodal MRI study reveals specific focal atrophy in the basal ganglia and limbic system. These structural and functional alterations are significantly more pronounced in patients who required hospitalisation, suggesting a severity-dependent impact on neural circuitry.

By Mishra, Pedersini, Misra, Yadav, Hafiz, Rokers, Biswal, Gandhi

#1605NeuroscienceFront Page6 December 2025

Sparking Trouble: Why Brain Stimulation Isn't a One-Size-Fits-All Cure

New research reveals that transcranial direct current stimulation (tDCS) affects healthy and neurodevelopmentally disordered brains in starkly different ways. While healthy mice can regulate the electrical boost, those modelling Angelman syndrome suffer from unchecked neuronal excitability.

By Agrawal, Abu Zeid, Kaphzan

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