
#1561Medicine & HealthFront Page1 January 2026
The Evolutionary Puzzle of T Cell Exhaustion: Why Our Defences Power Down
Chronic diseases trigger a specific, genetically programmed shutdown in immune cells rather than simple fatigue. This review outlines the metabolic and epigenetic shifts involved, suggesting that reversing this state requires more than just stimulating the immune system.
By Wu, Wu, Gao, Yu, Zhang, Zhou