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#1551Medicine & HealthFront Page15 November 2025

Hidden Brain Channel Fingered as a Key Driver of Epilepsy Seizures

Scientists have identified an ion channel, SUR1-TRPM4, that is overproduced in the epileptic brain. Normally rare, this channel boosts neuronal hyperactivity, promoting chronic seizures, and blocking its function in rodents has been shown to reduce seizure development, revealing a promising new target for anti-seizure therapies.

By Moyer, Ivanova, Keledijan, Kreinbrink, Langbein, Yang, McAfee, Boddeti, Khan, Owotade, Zhang, Benavides, Diamond, Zaghloul, Bachani, Gerzanich, Simard, Ksendzovsky

#1552Medicine & HealthFront Page12 November 2025

Brain Connectivity Reveals Two Distinct Flavours of Depression

Major depression isn't a single condition, according to a new study of brain activity. Researchers have identified two distinct, reproducible subtypes based on brain connectivity: one with weaker-than-normal connections and another with stronger ones, each linked to different genetic and neurochemical profiles.

By Li, Li, Long, Chen, Wang, Yang, DelBello, McNamara, Li, Gong

#1553NeuroscienceFront Page11 November 2025

Brain's Language Networks Underconnected in Non-Verbal Autism

A new study reveals widespread underconnectivity across key cognitive networks in non- or minimally verbal children with autism spectrum disorder (nvASD). This neural correlate offers crucial insights into the significant breakdown of language-related functions when language development is severely limited from a young age.

By Montaña-Valverde, Linke, Slušna, Muchart-López, Rodríguez-Fornells, Deco, Hinzen

#1554NeuroscienceFront Page19 January 2026

Decoding the Static: ALS Neuroimaging Biomarkers and the Spy Network Inside Your Head

Researchers compared traditional clinical methods against brain scan analysis to group ALS patients. The study suggests that data-driven neuroimaging detects widespread brain connectivity issues that standard physical checks might miss.

By Dey, Baumeister, Evans, Koppelmans, Luk, McLaren, Parnianpour, Seres, Kalra, Canadian A. L. S. Neuroimaging Consortium (CALSNIC)

#1555Medicine & HealthFront Page21 January 2026

Xenodiagnosis Fails to Substantiate Post-Treatment Lyme Disease Syndrome

A clinical trial investigating the use of sterile ticks to detect lingering Borrelia burgdorferi bacteria was terminated early due to futility. The study found no evidence of persistent infection in patients with chronic symptoms, suggesting the method is ineffective for this condition.

By Marques, Ng, McCarthy, Telford, Dardick, Wormser, Marcos, Tokarz, Williams, Law, Norville, Lundt, Petnicki-Ocwieja, Scavarda, McKenna, Goethert, Mateja, Follman, Eshoo, Hu

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