The Synaptic Report

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Results for "Genetics & Molecular Biology"

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#1531Genetics & Molecular BiologyFront Page4 December 2025

A Sticky Situation: How Cellular Adhesion Undermines Chemotherapy

New research identifies a rogue alliance between proteins CDC6 and Tmod3 as a primary driver of resistance to the common chemotherapy drug paclitaxel. By stabilising the cancer cell's internal skeleton and helping it anchor firmly, this interaction prevents the drug from taking effect, suggesting a novel target for combination therapies.

By Liu, Wang, Zhan, Sun, Sun, Fu, Lv, Li, Dong, Lou

#1532Medicine & HealthFront Page3 January 2026

The Silent Accomplice: Why **Triglycerides and Cardiovascular Disease** Demand a Second Look

Despite aggressive management of 'bad' cholesterol, heart attacks persist, driven by overlooked fats in the blood. Genetic evidence now identifies triglyceride-rich lipoproteins as active culprits rather than passive bystanders, prompting a shift toward targeted therapies. While new inhibitors show potent biological effects, their ability to save lives is still being tested.

By Alam, Mathai, Filtz, Kuno, Badimon, Sniderman, Virani, Toth, Shapiro, Lavie, Bhatt, Slipczuk

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