
#1431NeuroscienceFront Page6 January 2026
NAD+ and Brain Aging: The Choroid Plexus Control Switch
The enzyme CD38 accumulates in the brain's filtration system with age, depleting vital energy resources. A new drug, NTX-748, blocks this enzyme to restore metabolic function and reverse memory loss in mice.
By Verdin, Fang, Riley, Schneider, Perrone, Kumaar, King, Kauwe, Roberts, Hormazabal, Zhang, Millard, Liu, Jara, Aguirre, Baker, Murad, Ambrose, Tran, Martin, Zhang, Sellegounder, Melov, Furman, Tracy, Gerencser, Schilling, Ellerby