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#1411NeuroscienceFront Page12 December 2025

Beyond the Brain: How Gut and Blood Shape Parkinson's Disease Pathophysiology

Scientists are rethinking Parkinson's as a whole-body condition rather than just a brain disorder. By reviewing current data, they identified how gut bacteria and blood cells contribute to the toxic protein clumps that define the disease.

By Guo, Song, Wu, Zhang, Li, Yuan

#1412Medicine & HealthFront Page17 December 2025

Breaking the Grim Bargain: The Evolution of Mu Opioid Receptor Agonists

Researchers have identified a mechanism where specific agonists favour GTP release over binding, altering downstream signalling. In mouse models, this approach enhanced the pain-relieving effects of fentanyl without increasing respiratory depression.

By Stahl, Swanson, Dang, Cameron, Kennedy, Bannister, Bohn

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