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Results for "Genetics & Molecular Biology"

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#1211Medicine & HealthFront Page14 November 2025

Tuberculosis's Genetic Blueprint Shapes Its Attack on the Body

A massive 13-year study in Georgia reveals that the genetic makeup of tuberculosis bacteria plays a crucial role in treatment success. Researchers found specific bacterial mutations, beyond just drug resistance, that are linked to how severe the disease becomes, offering new paths for optimising treatments.

By Goig, Loiseau, Maghradze, Mchedlishvili, Avaliani, Tsutsunava, Brites, Kalkan, Borrell, Aspindzelashvili, Avaliani, Kipiani, Tukvadze, Jugheli, Gagneux

#1212Genetics & Molecular BiologyFront Page17 November 2025

Double Trouble: A New Drug Combination Decimates Liver Cancer Cells

Researchers have discovered that the enzyme ChaC1 strips liver cancer cells of their protective glutathione, leaving them vulnerable to the drug auranofin. By combining auranofin with proteasome inhibitors to boost ChaC1 levels, the team triggered catastrophic cell death, offering a promising new therapeutic strategy.

By Yu, Liu, Jian, Wen, Jiang, Zhang, Lin, Lin, Dai, Zhong, Zheng

#1213Environmental ScienceFront Page11 November 2025

Wild Coffee Species, Coffea dactylifera, Offers Hope for Climate-Resilient Breeding

Scientists have conducted the first multidisciplinary assessment of Coffea dactylifera, a wild coffee species from the Democratic Republic of Congo. This research reveals its potential for climate-resilient coffee breeding due to its unique genetic, climatic, and sensory characteristics. The findings highlight its importance for both conservation and the future sustainability of the global coffee industry.

By Tas, Bollen, Kambale, Bawin, de Backer, Janssens, Assumani, Stoffelen, Honnay, Vandelook

#1214Genetics & Molecular BiologyFront Page11 December 2025

ADPKD gene therapy: A precise edit for a complex organ

Researchers demonstrated that a single dose of an adenine base editor, delivered via AAV9, successfully corrected the pathogenic mutation in a mouse model of ADPKD. The study highlights that both broad and kidney-specific gene editing can delay cyst growth and improve survival rates.

By Cheng, Li, Zhou, Harris, Calvet, Li

#1215Genetics & Molecular BiologyFront Page5 December 2025

Genetic Choreography: Teaching Cells to Dance in Step

Researchers have developed a method to activate endogenous genes in a precise, sequential order, overcoming the limitations of simultaneous regulation. By manipulating RNA polymerase III termination, this system creates a programmable cascade essential for guiding complex cellular differentiation.

By Puppala, Nielsen, Regan, Mancinelli, De Pooter, Arnovitz, Harding, McGregor, Balanis, Clarke, Merrill

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