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Results for "Genetics & Molecular Biology"

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#1201Medicine & HealthFront Page14 November 2025

Tuberculosis's Genetic Blueprint Shapes Its Attack on the Body

A massive 13-year study in Georgia reveals that the genetic makeup of tuberculosis bacteria plays a crucial role in treatment success. Researchers found specific bacterial mutations, beyond just drug resistance, that are linked to how severe the disease becomes, offering new paths for optimising treatments.

By Goig, Loiseau, Maghradze, Mchedlishvili, Avaliani, Tsutsunava, Brites, Kalkan, Borrell, Aspindzelashvili, Avaliani, Kipiani, Tukvadze, Jugheli, Gagneux

#1202Genetics & Molecular BiologyFront Page17 November 2025

Double Trouble: A New Drug Combination Decimates Liver Cancer Cells

Researchers have discovered that the enzyme ChaC1 strips liver cancer cells of their protective glutathione, leaving them vulnerable to the drug auranofin. By combining auranofin with proteasome inhibitors to boost ChaC1 levels, the team triggered catastrophic cell death, offering a promising new therapeutic strategy.

By Yu, Liu, Jian, Wen, Jiang, Zhang, Lin, Lin, Dai, Zhong, Zheng

#1203Environmental ScienceFront Page11 November 2025

Wild Coffee Species, Coffea dactylifera, Offers Hope for Climate-Resilient Breeding

Scientists have conducted the first multidisciplinary assessment of Coffea dactylifera, a wild coffee species from the Democratic Republic of Congo. This research reveals its potential for climate-resilient coffee breeding due to its unique genetic, climatic, and sensory characteristics. The findings highlight its importance for both conservation and the future sustainability of the global coffee industry.

By Tas, Bollen, Kambale, Bawin, de Backer, Janssens, Assumani, Stoffelen, Honnay, Vandelook

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