Global Intelligence Database
Researchers have utilised advanced mass spectrometry to map protein changes in the brains of deceased heroin users. The study identifies significant alterations in proteins related to oxidative stress and neurodegeneration, suggesting that addiction causes structural cellular damage beyond simple receptor adaptation.
By Sürmen, Pence, Sürmen, Buyuk, Kuras, Elibol, Pence
Researchers have analysed the protein cargo of tiny particles called extracellular vesicles released by neurons during cortical spreading depolarization. The findings reveal that neurons undergo complex structural and metabolic adaptations during migraine events, potentially offering a new way to track the condition via biomarkers.
By Sever-Bahcekapili, Cakir-Aktas, Güler, Onat, Solgun, Şahin, Belder, Erdener, Salih, Dalkara
Researchers have engineered a novel molecular strategy that marries two-photon absorption with negative photoswitching. This approach yields ultra-sharp, four-photon-like imaging resolution while minimising the tissue damage typically associated with deep-dive microscopy.
By Benitez-Martin, Rouillon, Fron, de Jong, Grøtli, Hofkens, Pischel, Andréasson