Computer Science & AI27 November 2025

Reading Between the Lines: AI and Human Insight Decode Opioid Risks

Source PublicationJAMIA Open

Primary AuthorsPagare, Bheesetti, Essien-Aleksi et al.

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Buried within the often chaotic prose of clinical discharge summaries lies vital information about the social determinants of mental health (SDOMH)—factors crucial for treating patients with opioid use disorder (OUD). Historically, extracting these subtle cues from unstructured text has been a logistical nightmare for data scientists. However, a new study utilising the MIMIC-IV dataset suggests the solution isn't just smarter AI, but an AI that knows when to ask for help.

The researchers introduced a framework dubbed HLLIA, paired with a sophisticated algorithm known as MHCLE. While the acronyms are a mouthful, the concept is elegant: a 'human-in-the-loop' approach. Rather than letting a Large Language Model (LLM) run wild, the system integrates human expertise to refine the AI's annotations. This collaboration allows the software to parse complex narratives in patient notes, categorising 13 distinct social variables with remarkable precision.

The results are striking. The hybrid model achieved an accuracy of 96.29%, significantly outperforming established baselines like RoBERTa and ClinicalBERT. Interestingly, the study highlighted that human intervention was not merely a safety net but a performance booster; policies involving tighter human oversight yielded higher accuracy rates (up to 98.49%). By effectively mining these digital text mountains, clinicians may soon be better equipped to predict risks and intervene earlier in the OUD crisis.

Cite this Article (Harvard Style)

Pagare et al. (2025). 'Reading Between the Lines: AI and Human Insight Decode Opioid Risks'. JAMIA Open. Available at: https://doi.org/10.1093/jamiaopen/ooaf142

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Artificial IntelligenceOpioid Use DisorderNatural Language ProcessingMental Health