First 'On-Off Switch' for Genes Created in Hamsters, Boosting Disease Research

The golden Syrian hamster is a vital research model, sharing key biological similarities with humans in diseases like cancer and metabolic disorders. Yet, genetically engineering them has long lagged behind mice, partly due to technical challenges with their embryos.

Now, scientists have reported the first successful creation of a 'conditional knockout' hamster. Using the CRISPR/Cas9 gene-editing tool, they inserted special genetic markers called loxP sites around a target gene. This creates a conditional allele – essentially a gene with a pre-installed 'off switch'.

The switch can be activated in specific tissues, such as the heart or brain, by introducing another molecular tool. This gives researchers precise control over when and where a gene's function is disrupted. The technique proved highly efficient, with the genetic modification successfully passed to the next generation. This achievement provides a valuable new tool for disease modelling and understanding gene function.