Neuroscience

Left Area PF: The Brain's 'Technical Hub' Supporting Human Ingenuity

November 8, 2025From: Brain Structure and Function

Original Authors: Federico, Ilardi, Marangolo, Bryche, Metaireau, Bluet, Lesourd, Rossetti, Osiurak

Cover image for the article: Left Area PF: The Brain's 'Technical Hub' Supporting Human Ingenuity

Humans possess a distinctive capacity for technical reasoning—the ability to infer and manipulate the causal structure of the physical world. This faculty is central to technological innovation. Despite its importance, its neural substrates remain incompletely understood.

A recent study sheds light on this enigma, showing that grey matter volume in the left area PF, within the supramarginal gyrus of the inferior parietal lobule, may predict individual differences in technical reasoning in healthy adults (N = 75; 54 females; mean age = 20.92 ± 3.28 years). This association remains independent of demographic factors, personality traits, and total brain volume, highlighting its specific link to technical cognition. In contrast, grey matter volume in right prefrontal regions, examined solely as control areas, correlates with broader cognitive functions, such as fluid intelligence and abstract reasoning, but not with technical reasoning.

These findings suggest that the left area PF may provide essential computational resources for technical cognition. As lead author Federico notes in the paper, “Located in a parietal area that is disproportionately expanded in humans, the left area PF may serve as a technical hub, functioning as part of a broader fronto-temporo-parietal network that supports the human ability to generate, refine, and pass on complex technologies.” This discovery contributes to understanding the neural architecture of human ingenuity.

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technical reasoningneuroscienceleft area PFbrain volumeparietal lobetechnological innovation